NFL Week 10 Best Betting Picks, Predictions for Sunday November 10th

Oct 8, 2023; London United Kingdom, Buffalo Bills quarterback Josh Allen (17) carries the ball against Jacksonville Jaguars linebacker Josh Allen (41) during the first half of an NFL International Series game at Tottenham Hotspur Stadium. Mandatory Credit: Kirby Lee-Imagn Images

We’ve officially reached the second half of the NFL season.

The playoff picture is starting to officially take shape with Week 10 now here, with teams like the Kansas City Chiefs, Detroit Lions and Buffalo Bills all well-positioned to make deep runs this postseason.

Others, such as the New York Jets, Dallas Cowboys and San Francisco 49ers, had high expectations coming into the 2024 campaign but have vastly underperformed and are running out of time to turn things around.

Here are three of our best picks for Sunday:

Buffalo Bills at Indianapolis Colts

Ever since it dropped back-to-back games bridging September and October, Buffalo has been nearly unstoppable.

The Bills are riding a four-game winning streak and have averaged 29.5 points during that span, most recently hanging 30 on the Miami Dolphins in a three-point victory last Sunday.

Meanwhile, turning to Joe Flacco under center didn’t pay off for Indianapolis last weekend, as the veteran signal-caller threw for only 179 yards and was picked off once in a 21-13 setback against the Minnesota Vikings.

One offense is clicking, the other is in disarray, but oddsmakers seemingly have faith in the Colts’ ability to keep things close at home. Indianapolis is 3-1 at Lucas Oil Stadium this season, and it would be perfect there had it not been for a 29-27 loss to the Houston Texans in Week 1.

But the Colts faithful will only be able to do so much on Sunday. With dual-threat quarterback Josh Allen and running backs James Cook and Ray Davis, a budding offensive weapon, Buffalo should have no problem barreling through an Indianapolis defense that allows the second-most rushing yards per game in the NFL (149.8).

The pick: Bills spread -4, -108 (DraftKings)

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Denver Broncos at Kansas City Chiefs

Patrick Mahomes and Travis Kelce are starting to once again look like the dominant duo that has captivated the league for the past seven seasons.

Kelce has racked up 24 receptions (on 28 targets) for 190 yards and a touchdown over his past two games after catching 28 passes for 245 yards and no scores in his first six contests of the campaign.

Still, Kelce finding the end zone just once by this point in the season is just plain wrong. He has yet to haul in a TD at home, but we think that changes this week.

The pick: Travis Kelce anytime TD scorer, +115 (DraftKings)

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San Francisco 49ers at Tampa Bay Buccaneers

He’s back.

San Francisco star running back Christian McCaffrey is scheduled to make his season debut after working through Achilles tendinitis. He rushed for 1,459 yards and 14 touchdowns during the 2023 season, also grabbing 67 receptions for 564 yards and an additional seven scores.

When healthy, McCaffrey is the most dangerous back in the league. However, we aren’t under the impression that he is at 100 percent heading into the meeting with Tampa Bay.

After all, this is a guy who was supposedly in line to play in the 49ers’ season opener. Not only did that not happen, but he also went on to miss the next eight weeks.

The pick: Christian McCaffrey under 63.5 rushing yards, -115 (DraftKings)