NFL Week 6 Best Sports Betting Picks & Predictions for This Week’s Games

Jacksonville Jaguars quarterback Trevor Lawrence attempts a pass. PHOTO USA Today Sports Images

NFL London resumes after the Jets and Vikings tussled in England and only one team got back to work with the same head coach.

The Bears might look like the trendy pick this week, but the Jaguars are in a familiar—if international—environment. They’ve played in the UK series every year since 2013 with the exception of the COVID-19 hiatus in 2020 and won two games in London last season.

Jacksonville has only one win—a nail-biter over the Colts last week—but went 2-0 in London in 2023. Maybe the fish and chips platter will be just what Dr. Pederson ordered?

Lions at Cowboys, 4:25 p.m. ET

Detroit Lions -3, OVER 52.5 Total Points, Amon-Ra St. Brown Any Time Touchdown Scorer

Parlayed to push the value or of interest as standalones, the combination was +422 at FanDuel and +475 at Caesars 48 hours before kickoff.

Remember when “same old Lions” was a bad thing, and it might’ve led to an automatic bend to play the opposite side? We’re nearing opposite territory based on the burgeoning body of work put together by one of the NFL’s most talented teams.

There’s a revenge factor of sorts here if you buy into that year-after sort of schtick. Well, we know Dan Campbell is going to mention it in his locker room. The last time he was at AT&T Stadium, the Lions’ apparent go-ahead two-point conversion pass to Taylor Decker was wiped out by what Campbell felt was an imagined penalty for… illegal formation on Decker, who said he reported.

The Cowboys are down too many defenders in important roles to match the Lions blow for blow if this turns into a shootout, and, based on Detroit’s pliable defense to date, 52.5 is infinitely within reach. The Cowboys are winless at home (0-2) and the constancy of the pass rush, at least defensive end Aidan Hutchinson, means Dak Prescott will be throwing on the run, and desperation time could come early for Dallas.

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Bengals at Giants, 8:20 p.m. ET

Cincinnati Bengals -3.5, -110 BetMGM, FanDuel

Cincinnati covering anything after last week’s late-game debacle, which included a Joe Burrow interception and a botched hold on a game-winning field goal try, is worrisome. Ranking 31st in points allowed is doubly bad.

Speaking of worrisome, how is this Daniel Jones’ 13th primetime start?

And are you really buying the Giants in a game that will require them to score without WR Malik Nabers?

We aren’t, even though Jones has actually acquitted himself quite nicely with 20-plus completions in 11 of his 12 previous primetime starts.

He’s still not Burrow, and the Giants’ offense can’t compare to Cincinnati’s.

Burrow set a career high with five TD passes last week, and Cincinnati has too many weapons for the Giants to match up with in a high-scoring affair.

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Jaguars at Bears, 9:30 a.m. ET

Chicago Bears -1.5, -110 BetMGM, FanDuel

It’s getting late early for the Jaguars, appropriate for the football-for-breakfast stage they occupy this week. A deflated defense and concerns about the pecking order among playmakers have Jacksonville ripe for an implosion during this two-week stay in London.

The Bears are getting a lot of attention for their offense. It’s rounding into form since offensive coordinator Shane Waldron remembered getting the ball to running back D’Andre Swift is an option, and picking up the tempo has helped simplify some aspects of the scheme for rookie QB Caleb Williams.

Jacksonville can keep this game close because of the emergence of Tank Bigsby. He’s bringing more balance to the offense. But Trevor Lawrence, 3-1 in four career games in London, is being asked to carry too much weight while the defense stumbles. The Bears are built to take advantage of one-dimensional schemes, and if Chicago gets an early lead, this game has blowout potential to consider.